HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3'-(Trifluoromethyl)acetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| Reactant | Aldoxime | HCID 7863 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Product | 3'-(Trifluoromethyl)acetophenone | HCID 67682 | 70% |
Reaction Steps
A third example is described in Research Disclosure (1997), 402 (Oct) P706 (No. 40221), (CA 127:294925h). This reference teaches the multi-step reaction of 3-trifluoromethylaniline sequentially with a) aqueous sulfuric acid, b) aqueous sodium nitrite, c) aqueous acetaldoxime, d) cuprous sulfate and sodium bicarbonate and e) hydrochloric acid to form 3-trifluoromethylacetophenone in 70% yield. However, the overall volume efficiency of this process scheme is very low.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05969188 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-528ffe8cd6f24901856553a6267fec81 |
| Source note | uspto-grants-1999_10 |