1,2-Dichloroethane → HCID 21837229, compound

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Reaction Steps

To a stirred solution of 2-(2,2,2-trifluoroethoxy)-5-trifluoromethylphenylacetic acid (0.10 g, 0.33 mmol) from Step 3 above, 1-2-carbamoyl-4-(2-methylphenyl)piperazine (0.08 g, 0.36 mmol) from Step 4 of Example 1, and HOBT (0.06 g, 0.4 mmol) in DMF (5 mL) was added EDC (0.10 g, 0.5 mmol) and DIEA (0.088 mL, 0.5 mmol). The mixture was stirred at ambient temperature for 14 h. The solvent was removed under reduced pressure and the residue was purified by pressurized silica gel column chromatography using 5:95 MeOH:CH2Cl2 as eluant. The product-containing fractions were evaporated under reduced pressure to give the title compound as an amorphous powder.

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