HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetone → 1-(3-Ethyl-1-benzofuran-2-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetone | HCID 6571 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-Hydroxy-1-phenyl-1-propanone | HCID 101121 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(3-Ethyl-1-benzofuran-2-yl)ethanone | HCID 3860328 | 80% |
Reaction Steps
Reaction of hydroxypropiophenone (II) with chloroacetone (III) using potassium hydroxide in ethanol gives, by Stroemer-Schaefer condensation, 2-acetyl-3-ethylbenzofuran (IVj, R1 -R4 =H, R5 =C2H5, R6 =CH3) in a yield of about 80% (Belgian Patent Specification 553 621; (Chem. Abs. 5, 22016)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05972878 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-bc65c71016fb46ccafd861828f1cb05a |
| Source note | uspto-grants-1999_10 |