HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1740724Generated: November 2, 2026
Benzyl Alcohol → Boc-Iminodiacetic acid dibenzyl ester
https://huagongshe.com/reaction/1740724
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Boc-iminodi acetic acid | HCID 56923762 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Boc-Iminodiacetic acid dibenzyl ester | HCID 86754660 | — |
Reaction Steps
Boc-Iminodiacetic acid (5 g, 21.44 mmol), 4-dimethylaminopyridine (5.24 g, 42.87 mol), benzyl alcohol (4.64 g, 42.9 mmol) and HOBt (6.8 g, 43 mmol) were dissolved in CH2Cl2 (200 mL) and the solution was cooled to 0° C. DCC (8.84 g, 42.9 mmol) was added and the reaction was allowed to proceed at ambient temperature overnight. Precipitated dicyclohexylurea was filtered off and the filtrated was extracted with 4% aq NaHCO3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05972926 |
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| Source dataset | uspto-grants-1999_10 |
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| ORD ID | ord-ee1b608f8a754311ace9c7fd072f6371 |
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| Source note | uspto-grants-1999_10 |
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