Water → HCID 21833036, compound

Participants

Reaction Steps

6-Amino-N,N-dimethylchroman-4-acetamide (D8, 0.49 g, 2.1 mmol) was dissolved under Ar in dry THF (20 ml), and added to a stirred suspension of lithium aluminium hydride (0.16 g, 4.2 mmol) in dry THF (2 ml ). The mixture wa s stirred at reflux for 3 h, cooled, and treated successively with water (0.16 ml), 10% NaOH (0.16 ml) and water (0.48 ml) The solid was filtered off, and the filtrate was evaporated to give the title compound (0.41 g, 97%) as a red oil.

Provenance & Evidence