Hydrochloric Acid → HCID 18694219, compound

Participants

Reaction Steps

Methyl 4'-amino-2'-methylbiphenyl-4-carboxylate (D27) (1.84 g, 7.6 mmol) and triethylamine (2.6 ml, 19 mmol) were stirred in dichloromethane (100 ml) as 4-chlorobutyryl chloride (0.94 ml, 8.4 mmol) was added dropwise. The mixture was stirred for 1 h, vigorously stirred with water for 15 min, acidified (5M HCl), and separated. The organic phase was washed with water and K2CO3 /brine solution, dried (Na2SO4) and evaporated to give a light yellow solid. Chromatography on silica gel, eluting with 0-40% ether/dichloromethane, gave the title compound (1.08 g, 41%) as a light yellow solid.

Provenance & Evidence