Pyridine → HCID 70108068, compound

Participants

Reaction Conditions

Reaction Steps

4.71 g (18.6 mmol) of 7-benzoyl-5-methoxyindoline are introduced into 75 ml of pyridine, followed by 16.2 g (116 mmol) of ethyl glycinate hydrochloride. The mixture is heated to 110-115° C. with stirring while distilling off the light fractions which form. After 12 hours, the mixture is cooled and 100 ml of a 2.5% solution of sodium carbonate in water and 100 ml of dichloromethane are added. The aqueous phase is separated out and extracted with 100 ml of dichloromethane. The organic phases are combined and washed with water. The solvent is evaporated off and the residue is then purified by flash chromatography on a column of silica, the eluent used being a gradient of acetone in dichloromethane. 4.15 g of purified product in the form of a brown resin are obtained.

Provenance & Evidence