HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 15435719, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 21833186 | HCID 21833186 | — |
| Reactant | HCID 23693685 | HCID 23693685 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 15435719 | HCID 15435719 | — |
Reaction Steps
To sodium 6-(4-methylpiperazinyl)pyridine-3-carboxylate and 14-aminotetradecyl nitrate was added 150 ml of methylene chloride and then 6.80 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (WSCI) and 5.00 g of 1-hydroxybenzotriazole (HOBt) were added at room temperature while stirring and then the mixture was stirred at room temperature for 15 hours. The reaction solution was chromatographed over a silica gel column and the residue was purified by recrystallization to afford the title compound as a colorless crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05972943 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-b67051f69f9c4208a9090aadad60548f |
| Source note | uspto-grants-1999_10 |