Piperazine → 1-[4-(Propan-2-yl)piperazin-1-yl]ethan-1-one

Participants

Reaction Conditions

Reaction Steps

To a mixture of 12.95 g of piperazine, 0.75 g of sodium iodide and 3.46 g of potassium carbonate were added successively 25 ml of methanol and 6.15 g of 2-bromopropane and the mixture was stirred at 60° C. for 4 hours. Chloroform was added, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, 12 ml of acetic anhydride was added gradually and the mixture was stirred at room temperature for 2.5 hours. The reaction solution was poured into ice, chloroform was added and then it was neutralized with sodium carbonate. After extracted with chloroform, the extract was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue thus obtained was chromatographed over a silica gel column and the solvent was distilled off. The residue thus precipitated out was allowed to stand overnight and the diacetylpiperazine was filtered off to afford 7.26 g of the title compound as an oily substance.

Provenance & Evidence