HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → 5-Methoxy-6-(trifluoromethyl)indoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 5-Methoxy-6-(trifluoromethyl)-1H-indole | HCID 10822552 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Methoxy-6-(trifluoromethyl)indoline | HCID 11206713 | 99% |
Reaction Steps
The indole (D28) (67.63 g, 0.315 mol) was treated with sodium cyanoborohydride (40 g, 0.637 mol) in glacial acetic acid (500 ml) as in the method of Description 16 to afford the title indoline (67.73 g, 99%) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05972937 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-45620977afb4457fb66ea35d8800366f |
| Source note | uspto-grants-1999_10 |