Phenyl isocyanate → 1-[Phenylcarbamoyl]-5-methylthio-6-trifluoromethyl indoline

HRID 1740812Notes

Reaction equation

HRID 1740812 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:10][S:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][C:20]=1[C:21]([F:24])([F:23])[F:22])[NH:17][CH2:16][CH2:15]2>>[C:1]1([NH:7][C:8]([N:17]2[C:18]3[C:14](=[CH:13][C:12]([S:11][CH3:10])=[C:20]([C:21]([F:22])([F:24])[F:23])[CH:19]=3)[CH2:15][CH2:16]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 7672Phenyl isocyanateHCID 106572701H-Indole, 2,3-dihydro-5-(methylthio)-6-(trifluoromethyl)-

Product 1

HCID 218331061-[Phenylcarbamoyl]-5-methylthio-6-trifluoromethyl indolineYield 34%

Procedure

This was prepared from phenyl isocyanate and 5-methylthio-6-trifluoromethyl indoline in 34% yield m.p. 163-165° C.

Sources & evidence

ORD record
ord-3620189cb4bd4538b2d7c4167d6cefbe
Source dataset
uspto-grants-1999_10
Patent number
US05972937

Reaction notes

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