Sodium Carbonate → HCID 21833078, compound

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Reaction Steps

A mixture of 5-methoxy-6-trifluoromethyl-1-(5-bromo-2-thienyl) carbamoyl indoline (E48) (0.64 g, 1.5 mmol), sodium carbonate (1.1 g), pyridine-3-boronic acid (0.55 g, 4.5 mmol) and tetrakis triphenylphine palladium(0) (0.1 g) in dimethoxyethane/water (20 ml/5 ml) was heated to reflux overnight under argon. Extraction workup and chromatography afforded the title compound in 27% yield as a white solid, m.p. 240-244° C.

Provenance & Evidence