反应详情

A mixture of 3 g of 2-chloro-4-(2-2H-1,2,3-triazolyl)methylphenyl 2,2-dimethylpropanoate, 10 ml of 20% aqueous sodium hydroxide solution and 60 ml of ethanol was heated at reflux for 5 hours. The reaction mixture was then concentrated under reduced pressure, to which water was added, and the mixture was adjusted to pH 6.0 with concentrated hydrochloric acid. This mixture was extracted with ethyl acetate. The organic layer was washed with water, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, which afforded 2-chloro-4-(2-2H-1,2,3-triazolylmethyl)phenol.

1. temperaturewas heated
2. temperatureat reflux for 5 hours
3. concentrationThe reaction mixture was then concentrated under reduced pressure, to which water
4. additionwas added
5. extractionThis mixture was extracted with ethyl acetate
6. washThe organic layer was washed with water
7. dry with materialdried with anhydrous magnesium sulfate
8. concentrationconcentrated under reduced pressure