反应详情

To a solution of 5 g (0.0122 mole) of ethyl (Z)-3-(4-chlorophenyl)-3-(4-methanesulphonylphenyl)-2-(2-hydroxyethyl)prop-2-enoate, prepared in example 4, in 10 ml of ethanol are added 11 ml (0.011 mole) of 1 M sodium hydroxide. The mixture is heated for 2 hours under reflux, then evaporated to dryness in vacuo. The crystals obtained are washed with ethyl acetate and with diethyl ether and then dried to provide 4.5 g of sodium (Z)-3-(4-chlorophenyl)-3-(4-methanesulphonylphenyl)-2-(2-hydroxyethyl)prop-2-enoate as crystals with melting point of 257-259° C.

1. temperatureThe mixture is heated for 2 hours
2. temperatureunder reflux
3. customevaporated to dryness in vacuo
4. customThe crystals obtained
5. washare washed with ethyl acetate and with diethyl ether
6. customdried