Water → HCID 9865107, compound

Participants

Reaction Steps

A solution of 230 mg of the ethyl ester prepared in e) in 2 ml tetrahydrofuran and 1 ml water is admixed with 0.7 ml 1 n sodium hydroxide solution and stirred for 1 h at room temperature. Subsequently the tetrahydrofuran is removed in a vacuum and the product is purified by means of an ion exchanger (Dowex 50, H form). 120 mg of the title compound is obtained in this way as a white powder. FAB=388; 1H-NMR (d6 -DMSO) δ=8.15 ppm (d, 2H); 6.82 (d, 2H); 4.60 (m, 1H); 4.02 (broad d, 2H); 3.75 (m, 1H); 3.50 (t, 1H); 3.15 (dd, 1H); 2.95 (broad d, 2H); 2.80 (m, 2H); 2.52 (m, 2H); 2.10 (m, 3H); 1.80-1.40 (m, 8H).

Provenance & Evidence