Water → HCID 43119952, compound

Participants

Reaction Steps

A mixture of 3.1 g piperidine-4-carboxylic acid ethyl ester, 6.4 ml epichlorohydrin and 0.1 g tetrabutylammonium bromide in 15 ml toluene and 15 ml concentrated sodium hydroxide solution is stirred for 4 h at room temperature and subsequently admixed with 50 ml water. The organic phase is removed, the aqueous phase is shaken three times with 20 ml methylene chloride each time, the combined organic phases are dried over sodium sulfate and the solvent is removed in a vacuum. 2.1 g (rac)-1-oxiran-2-ylmethylpiperidine-4-carboxylic acid ethyl ester is obtained. m/e=213.

Provenance & Evidence