2-Amino-N-(4-chlorophenyl)-N-methylacetamide → HCID 21833477, compound

HRID 1740852Notes

Reaction equation

HRID 1740852 reaction equation
Cl[C:2]1[C:7]([CH2:8][CH3:9])=[C:6]([CH3:10])[N:5]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1.[NH2:17][CH2:18][C:19]([N:21]([C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=1)[CH3:22])=[O:20].ClC1C(C)=C(C)N=C(C2C=CC=CC=2)N=1.NCC(N(CCC)CCC)=O>>[Cl:29][C:26]1[CH:25]=[CH:24][C:23]([N:21]([CH3:22])[C:19](=[O:20])[CH2:18][NH:17][C:2]2[C:7]([CH2:8][CH3:9])=[C:6]([CH3:10])[N:5]=[C:4]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:3]=2)=[CH:28][CH:27]=1

Participants

5

Reactant 4

HCID 126035712-Amino-N-(4-chlorophenyl)-N-methylacetamideHCID 127424812-amino-N,N-dipropyl-acetamideHCID 134879354-Chloro-5,6-dimethyl-2-phenylpyrimidineHCID 13487936HCID 13487936, compound

Product 1

HCID 21833477HCID 21833477, compound

Procedure

The same procedures as Example 1 are repeated except that 4-chloro-5-ethyl-6-methyl-2-phenylpyrimidine and 2-amino-N-(4-chlorophenyl)-N-methylacetamide are used instead of 4-chloro-5,6-dimethyl-2-phenylpyrimidine and 2-amino-N,N-dipropylacetamide, respectively. The product thus obtained is recrystallized from isopropanol to give the desired compound, m.p. 142-143° C.

Workup

  1. customThe product thus obtained
  2. customis recrystallized from isopropanol

Sources & evidence

ORD record
ord-18ef8b05ae42441794ac9688e34d6ec0
Source dataset
uspto-grants-1999_10
Patent number
US05972946

Reaction notes

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