HCID 21833453, compound → 2-(5-amino-2-phenyl-4-pyrimidinylamino)-N,N-dipropylacetamide

HRID 1740857Notes

Reaction equation

HRID 1740857 reaction equation
[N+:1]([C:4]1[C:5]([NH:16][CH2:17][C:18]([N:20]([CH2:24][CH2:25][CH3:26])[CH2:21][CH2:22][CH3:23])=[O:19])=[N:6][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][CH:9]=1)([O-])=O>[C].[Pd].C(O)C>[NH2:1][C:4]1[C:5]([NH:16][CH2:17][C:18]([N:20]([CH2:24][CH2:25][CH3:26])[CH2:21][CH2:22][CH3:23])=[O:19])=[N:6][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][CH:9]=1

Participants

4

Reactant 1

HCID 21833453HCID 21833453, compound

Product 1

HCID 218334922-(5-amino-2-phenyl-4-pyrimidinylamino)-N,N-dipropylacetamideYield 86.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A mixture of 2-(5-nitro-2-phenyl-4-pyrimidinylamino)-N,N-dipropylacetamide (1.9 g) obtained in Example 121, ethanol (60 ml) and 10% palladiumcarbon (0.2 g) is stirred at room temperature for three hours under hydrogen atmosphere, and the reaction mixture is filtered. The filtrate is concentrated under reduced pressure, and recrystallized from diethyl ether to give the desired compound (1.5 g), m.p. 120-122° C.

Workup

  1. filtrationthe reaction mixture is filtered
  2. concentrationThe filtrate is concentrated under reduced pressure
  3. customrecrystallized from diethyl ether

Sources & evidence

ORD record
ord-10cc63f2696a4cd0b97128ac0efd48fb
Source dataset
uspto-grants-1999_10
Patent number
US05972946

Reaction notes

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