反应详情

A mixture of 2-(5-nitro-2-phenyl-4-pyrimidinylamino)-N,N-dipropylacetamide (1.9 g) obtained in Example 121, ethanol (60 ml) and 10% palladiumcarbon (0.2 g) is stirred at room temperature for three hours under hydrogen atmosphere, and the reaction mixture is filtered. The filtrate is concentrated under reduced pressure, and recrystallized from diethyl ether to give the desired compound (1.5 g), m.p. 120-122° C.

1. filtrationthe reaction mixture is filtered
2. concentrationThe filtrate is concentrated under reduced pressure
3. customrecrystallized from diethyl ether