HCID 10536983, compound → HCID 15871401, compound

HRID 1740861Notes

Reaction equation

HRID 1740861 reaction equation
[CH3:1][C:2]1[C:3](=[O:18])[NH:4][C:5]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[N:6][C:7]=1[CH3:8].Br[CH2:20][C:21]([N:23]([CH2:30][CH3:31])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:22].CC1C(=O)NC(C2C=CC=CC=2)=NC=1C.BrCC(N(CCC)CCC)=O>>[CH2:30]([N:23]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:21](=[O:22])[CH2:20][O:18][C:3]1[C:2]([CH3:1])=[C:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:10]=[CH:11][C:12]([N+:15]([O-:17])=[O:16])=[CH:13][CH:14]=2)[N:4]=1)[CH3:31]

Participants

5

Reactant 4

HCID 10536983HCID 10536983, compoundHCID 15215996HCID 15215996, compoundHCID 135527547HCID 135527547, compoundHCID 135966602HCID 135966602, compound

Product 1

HCID 15871401HCID 15871401, compound

Procedure

The same procedures as Example 136 are repeated except that 5,6-dimetyl-2-(4-nitrophenyl)-4-(3H)-pyrimidinone and 2-bromo-N-ethyl-N-phenylacetamide are used instead of 5,6-dimethyl-2-phenyl-4-(3H)-pyrimidinone and 2-bromo-N,N-dipropylacetamide, respectively. The product thus obtained is recrystallized from acetonitrile to give the desired compound, m.p. 89-190° C.

Workup

  1. customThe product thus obtained
  2. customis recrystallized from acetonitrile

Sources & evidence

ORD record
ord-74c29ca303b24dfebe59b41b988b586f
Source dataset
uspto-grants-1999_10
Patent number
US05972946

Reaction notes

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