2-bromo-n,n-dipropylpropanamide → HCID 21833471, compound

HRID 1740863Notes

Reaction equation

HRID 1740863 reaction equation
[C:1]1([C:7]2[NH:16][C:15](=[O:17])[C:14]3[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH:19]([CH3:29])[C:20]([N:22]([CH2:26][CH2:27][CH3:28])[CH2:23][CH2:24][CH3:25])=[O:21].CC1C(=O)NC(C2C=CC=CC=2)=NC=1C.BrCC(N(CCC)CCC)=O>>[C:1]1([C:7]2[N:16]=[C:15]([O:17][CH:19]([CH3:29])[C:20]([N:22]([CH2:23][CH2:24][CH3:25])[CH2:26][CH2:27][CH3:28])=[O:21])[C:14]3[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=3[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 4

HCID 2255512-bromo-n,n-dipropylpropanamideHCID 10536983HCID 10536983, compoundHCID 135440564HCID 135440564, compoundHCID 135527547HCID 135527547, compound

Product 1

HCID 21833471HCID 21833471, compound

Procedure

The same procedures as Example 136 are repeated except that 5,6,7,8-tetrahydro-2-phenyl-4-(3H)-quinazolinone and 2-bromo-N,N-dipropylpropanamide are used instead of 5,6-dimethyl-2-phenyl-4-(3H)-pyrimidinone and 2-bromo-N,N-dipropylacetamide, respectively. The product thus obtained is recrystallized from n-hexane to give the desired compound, m.p. 73-74° C.

Workup

  1. customThe product thus obtained
  2. customis recrystallized from n-hexane

Sources & evidence

ORD record
ord-aea7bb2b6f7542a59ae1913cd030f364
Source dataset
uspto-grants-1999_10
Patent number
US05972946

Reaction notes

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