Ethanol → HCID 21834080, compound

HRID 1740870Notes

Reaction equation

HRID 1740870 reaction equation
[NH2:1][C:2]1[C:3](=[O:25])[NH:4][C:5]2[C:10]([C:11]=1[C:12]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20])=[CH:9][C:8]([C:21]([F:24])([F:23])[F:22])=[CH:7][CH:6]=2.[NH:26]1[C:30]2[CH:31]=[CH:32][CH:33]=[C:34](CO)[C:29]=2[N:28]=[N:27]1.[CH2:37](O)C>>[Cl:18][C:16]1[CH:15]=[CH:14][C:13]([O:19][CH3:20])=[C:12]([C:11]2[C:10]3[C:5](=[CH:6][CH:7]=[C:8]([C:21]([F:22])([F:24])[F:23])[CH:9]=3)[NH:4][C:3](=[O:25])[C:2]=2[NH:1][CH2:37][N:26]2[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[N:28]=[N:27]2)[CH:17]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 154631583-Amino-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-oneHCID 178519450HCID 178519450, compound

Product 1

HCID 21834080HCID 21834080, compoundYield 71.6%

Procedure

A solution of 3-amino-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one(500 mg, 1.36 mmol), benzotriazole methanol (202.9 mg, 1.36 mmol) and absolute ethanol (5 mL) was heated to 60° C. overnight (18 hours). The resulting suspension was then cooled and the solids were collected. The solids were then washed with ethanol and air dried affording 4-(5-chloro-2-methoxyphenyl)-3-[[(1H-benzotriazol-1-yl)methyl]amino]-6-(trifluoromethyl)quinolin-2(1H)-one (487 mg, 71.6%).

Workup

  1. temperatureThe resulting suspension was then cooled
  2. customthe solids were collected
  3. washThe solids were then washed with ethanol and air
  4. customdried

Sources & evidence

ORD record
ord-98c093bb8ce046ff8246a7b8f4be052b
Source dataset
uspto-grants-1999_10
Patent number
US05972961

Reaction notes

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