Benzenesulfonyl chloride → HCID 1237760, compound

Participants

Reaction Steps

To a solution of 10.0 g, 52.6 mmol, of 4-amino-1-benzyl-piperidine in 150 ml of dichloromethane was added 1.36 g (53 mmol) of benzene sulfonylchloride. The solution was stirred for 1 hour at room temperature, diluted with 500 mL of dichloromethane and washed with 5% aqueous sodium hydroxide followed by water and brine. The organic phase was separated, dried (MgSO4), and concentrated in vacuo to give 16.6 g of product as an oil. The compound was used without further purification.

Provenance & Evidence