Thionyl Chloride → HCID 21834319, compound

HRID 1740885Notes

Reaction equation

HRID 1740885 reaction equation
O[CH2:2][C:3]1[NH:4][C:5]2[CH:11]=[C:10]([O:12][C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.S(Cl)([Cl:21])=O>>[ClH:21].[ClH:21].[Cl:21][CH2:2][C:3]1[NH:4][C:5]2[CH:11]=[C:10]([O:12][C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 9881262HCID 9881262, compound

Product 1

HCID 21834319HCID 21834319, compound

Procedure

A 250-ml round-bottomed flask equipped with a stirrer and a condenser is charged with 3.18 g (13.2 mmol) of 2-hydroxymethyl-5-(4-pyridyloxy)benzimidazole obtained in Example 1 and 40 ml of thionyl chloride. The mixture is brought to reflux for 2 hours and then cooled. The precipitate is filtered off, washed with ether and dried, and yields the expected product.

Workup

  1. customA 250-ml round-bottomed flask equipped with a stirrer and a condenser
  2. temperatureto reflux for 2 hours
  3. temperaturecooled
  4. filtrationThe precipitate is filtered off
  5. washwashed with ether
  6. customdried

Sources & evidence

ORD record
ord-83abc469592a4c8aace0fe55a166c753
Source dataset
uspto-grants-1999_10
Patent number
US05972968

Reaction notes

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