Sodium Carbonate → 4-Methyl-5-pentyl-2-pyridinamine

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-methyl-2-(trimethylacetyl)amino-5-(1-pentyl)-pyridine (233 mg, 0.89 mmol) in 2N hydrochloric acid (3 mL) was heated at 100° C. for 18 h. The solution was cooled to room temperature, made basic with 20% aqueous sodium carbonate and extracted with chloroform. The organic layer was dried (Na2SO4), and evaporated. The product was purified by silica gel column chromatography using 2% methanol/methylene chloride to give the title compound.

Provenance & Evidence