Hydrochloric Acid → HCID 21834416, compound

Participants

Reaction Steps

N-Acetyl-α-(2-(6-amino-4-methylpyrid-2-yl)ethyl)glycine methyl ester (200 mg, 0.75 mmol) was heated in 6.0 mL of refluxing 2 N aqueous hydrochloric acid for 2.5 h. The solution was cooled and evaporated. The residue was dissolved in 2.75 mL of warm methanol and the solution was concentrated to a volume of 1-1.5 mL. Ethyl acetate (1.0 mL) and seed crystals were added. The crystals were separated using a Craig tube and recrystallized again to give 122 mg (58% yield) of α-(2-(6-amino-4-methylpyrid-2-yl)ethyl)glycine dihydrochloride as white crystals.

Provenance & Evidence