2-(2,5-Dimethyl-1H-pyrrol-1-yl)-4,6-dimethylpyridine → HCID 18393830, compound

HRID 1740996Notes

Reaction equation

HRID 1740996 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([N:9]2[C:13]([CH3:14])=[CH:12][CH:11]=[C:10]2[CH3:15])[CH:3]=1.Br[CH2:17][C@H:18]([N:20]1[C:24]([CH3:25])=[CH:23][CH:22]=[C:21]1[CH3:26])[CH3:19]>>[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:17][C@H:18]([N:20]2[C:24]([CH3:25])=[CH:23][CH:22]=[C:21]2[CH3:26])[CH3:19])[N:5]=[C:4]([N:9]2[C:13]([CH3:14])=[CH:12][CH:11]=[C:10]2[CH3:15])[CH:3]=1

Participants

3

Reactant 2

HCID 224907362-(2,5-Dimethyl-1H-pyrrol-1-yl)-4,6-dimethylpyridineHCID 54215954HCID 54215954, compound

Product 1

HCID 18393830HCID 18393830, compound

Procedure

By analogy to Example 76, Step A, the anion of 4,6-dimethyl-2-(2,5-dimethylpyrrol-1-yl)pyridine was alkylated with (R)-1-(2-bromo-1-methylethyl)-2,5-dimethylpyrrole to give (R)-4-methyl-2-(2,5-dimethylpyrrol-1-yl)-6-(3-(2,5-dimethylpyrrol-1-yl)-3-methylpropyl)pyridine.

Sources & evidence

ORD record
ord-4fc74a0e700147cf958bdc70efcaba84
Source dataset
uspto-grants-1999_10
Patent number
US05972975

Reaction notes

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