Acetic Anhydride → N-((4-Methoxyphenyl)sulfonyl)-N-(2-((1E)-2-(1-oxido-4-pyridinyl)ethenyl)phenyl)-acetamide

HRID 1741022Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2/[CH:19]=[CH:20]/[C:21]2[CH:26]=[CH:25][N+:24]([O-:27])=[CH:23][CH:22]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[C:28](OC(=O)C)(=[O:30])[CH3:29]>>[C:28]([N:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1/[CH:19]=[CH:20]/[C:21]1[CH:22]=[CH:23][N+:24]([O-:27])=[CH:25][CH:26]=1)[S:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)(=[O:11])=[O:10])(=[O:30])[CH3:29]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 178492875HCID 178492875, compound

Product 1

HCID 9888590N-((4-Methoxyphenyl)sulfonyl)-N-(2-((1E)-2-(1-oxido-4-pyridinyl)ethenyl)phenyl)-acetamide

Procedure

Using 1.54 g of the compound obtained in Example 20, the reaction was conducted in the presence of acetic anhydride at 140° C. for 10 minutes and, then, after-treated. The crystal crop was recrystallized from ethanol to provide 0.62 g of the title compound (white granules). m.p. 235-237° C. (decomp.)

Workup

additionafter-treated
customThe crystal crop was recrystallized from ethanol

Sources & evidence

ORD record: ord-c7f0400ad3da411194364c48bca8f78b
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05972976

Reaction notes

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