2,3-Dihydro-1'-methyl-5-nitrospiro[benzofuran-3,4'-piperidine] → 5-Amino-2,3-dihydro-1'-methylspiro[benzofuran-3,4'-piperidine]

Participants

Reaction Steps

2,3-Dihydro-1'-methyl-5-nitrospiro[benzofuran-3,4'-piperidine] (D4, 0.98 g, 4.0 mmol) was hydrogenated over 10% palladium on charcoal (0.18 g) in ethanol (50 ml) for 6 h. Catalyst was filtered off onto kieselguhr, and the filtrated was evaporated and chromatographed on silica gel, eluting with 0-25% methanol/chloroform (gradient), to give the title compound (0.52 g, 60%) as a cream solid.

Provenance & Evidence