Hydrochloric Acid → 2,5,6,7,8,9-Hexahydro-1′-methylspiro[3H-furo[2,3-h][1]benzazepine-3,4′-piperidine]

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Reaction Steps

5-Acetyl-3,5,6,7,8,9-hexahydro-1'-methylspiro [2H-furo[2,3-h]benzazepine-3,4'-piperidine] (D27, 0.25 g, 0.82 mmol) was stirred at reflux under Ar in c. HCl (15 ml) for 4 days. It was then evaporated to dryness, dissolved in dichloromethane, washed with K2CO3 solution, dried (Na2SO4) and evaporated to give the title compound (0.203 g) as a brown gum, still containing ca. 15% of amide (NMR). Chromatography on silica, eluting with 0-15% methanol in dichloromethane, give purer material (0.107 g, 49%)

Provenance & Evidence