Dimethylamine → 4-Bromo-N,N-dimethylbenzenesulphonamide

HRID 1741060Notes

Reaction equation

HRID 1741060 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:12][NH:13][CH3:14]>ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:13]([CH3:14])[CH3:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 7396p-Bromobenzenesulfonyl chloride

Product 1

HCID 128184-Bromo-N,N-dimethylbenzenesulphonamideYield 94%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Bromobenzenesulphonyl chloride (4.48 g, 18 mmol) was stirred in dichloromethane, and dimethylamine (40% aqueous solution, 10 ml) was added portionwise. The mixture was stirred for 2 h, washed with dilute hydrochloric acid, dried (Na2SO4) and evaporated to give the title compound (4.38 g, 94%) as a white solid.

Workup

  1. washwashed with dilute hydrochloric acid
  2. dry with materialdried (Na2SO4)
  3. customevaporated

Sources & evidence

ORD record
ord-433c18149c2844f4a83f95994c969cd9
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

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