4-Pyridineethanol → HCID 21833786, compound

HRID 1741065Notes

Reaction equation

[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([OH:14])=[C:10]([Br:13])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[N:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH2:22]O)=[CH:17][CH:16]=1>>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([O:14][CH2:22][CH2:21][C:18]3[CH:19]=[CH:20][N:15]=[CH:16][CH:17]=3)=[C:10]([Br:13])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 729214-Pyridineethanol

HCID 219483801-(6-Bromo-5-hydroxy-2,3-dihydro-1H-indol-1-yl)ethan-1-one

Product 1

HCID 21833786HCID 21833786, compoundYield 84%

Procedure

This was prepared from 1-acetyl-6-bromo-2,3-dihydro-1H-indol-5-ol (Tetrahedron 1973, 29(8), 1115) and 2-(4-pyridyl)ethanol (D65), following the procedure of Description 8a. This gave the title compound (84%), as a yellow solid.

Sources & evidence

ORD record: ord-155f6b8ffbd440718c809c41f9d7baf0
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05972951

Reaction notes

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