Acetic Anhydride → N'-acetyl-4-bromo-3-methyl-benzohydrazide

HRID 1741066Notes

Reaction equation

HRID 1741066 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][C:3]=1[CH3:12].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[C:13]([NH:9][NH:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([Br:1])=[C:3]([CH3:12])[CH:4]=1)(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 39058874-Bromo-3-methylbenzohydrazide

Product 1

HCID 21833789N'-acetyl-4-bromo-3-methyl-benzohydrazide

Procedure

4-Bromo-3-methylbenzoic hydrazide (D30, 7.5 g) was suspended in acetic anhydride (7 ml) giving rise to an exothermic reaction. The reaction mixture was cooled to room temperature and the product collected. The solid was washed with ethanol and diethyl ether to afford the title compound as a white powder (5.5 g).

Workup

  1. customgiving rise
  2. customto an exothermic reaction
  3. customthe product collected
  4. washThe solid was washed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-e155852771c64c7daa61ba8f5c1c9111
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

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