HCID 131721415, compound → HCID 21833752, compound

Participants

Reaction Steps

A solution of 2,3-dihydro-1'-methylspiro[4H-pyrano[2,3-g]quinoline-4,4' piperidine] (D106, 150 mg, 0.0006 mole) in ethanol (50 ml) and glacial acetic acid (2 ml) was hydrogenated over PtO2 (35 mg) at 50 psi for 2 days. The catalyst was removed by filtration through kieselguhr and the filtrate concentrated in vacuo. The residue was purified by chromatography on silica gel eluting with 30% MeOH/dichloromethane with 1% ammonia solution to afford the title compound (150 mg, 99%).

Provenance & Evidence