HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-1,2,3,6-tetrahydropyridine-4-methanol → 1'-Ethyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-1,2,3,6-tetrahydropyridine-4-methanol | HCID 21833764 | — |
| Reactant | 1-(6-Bromo-5-hydroxy-2,3-dihydro-1H-indol-1-yl)ethan-1-one | HCID 21948380 | — |
| Product | 1'-Ethyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] | HCID 21833744 | 45% |
Reaction Steps
This was prepared from 1-acetyl-6-bromo-2,3-dihydro-1H-indol-5-ol (Tetrahedron, 1973, 29 (8), 1115) and 1-ethyl-1,2,3,6-tetrahydropyridine-4-methanol (D108), following the procedure of Description 8 (alternative preparation), steps a), b), and c). This gave the title compound (overall yield: 45%) as a fine grey powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05972951 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-c1b6dac6d55641e2af46456e7797745e |
| Source note | uspto-grants-1999_10 |