Water → HCID 21833817, compound

Participants

Reaction Steps

4'-Amino-2'-methylbiphenyl-4-carboxylic acid (D115, 2.45 g, 10.8 mmol) and triethylamine (3.8 ml, 27.3 mmol) were stirred in dichloromethane (50 ml) as chloroacetyl chloride (1.05 ml, 13.2 mmol) was added dropwise. This mixture was stirred for 3 h, when water (20 ml) was added. After vigorous stirring for 15 min and basification with potassium carbonate solution, the mixture was separated. The aqueous portion was washed with dichloromethane, and acidified with conc. hydrochloric acid. The precipitated solid was filtered off and dried, giving the title compound (1.33 g, 40%) as a grey powder.

Provenance & Evidence