HRID1741103

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1nnc(-c2ccc(-c3ccc(C(=O)O)cc3)c(C)c2)o1

HCID18690066

未命名化合物

HCID21948380

1-(6-Bromo-5-hydroxy-2,3-dihydro-1H-indol-1-yl)ethan-1-one

C10H10BrNO2

HCID70198004

未命名化合物

PRODUCTS

生成物

结构：Cc1nnc(-c2ccc(-c3ccc(C(=O)n4ccc5cc6c(cc54)C4(CCN(C)CC4)CO6)cc3)c(C)c2)o1

HCID21833853

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 2,3-dihydro-1'-methylspiro[furo[2,3-f]indole-3,4'-piperidine] (D7) and 2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxylic acid (D11) using a similar procedure to Example 8 (22%). This was converted to its oxalate salt, which crystallised from acetone/methanol as a white solid mp 234-237° C.

WORKUP

后处理

customcrystallised from acetone/methanol as a white solid mp 234-237° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bc131c666a3848bda30bb7eada4c8076
来源数据集: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05972951
来源说明: uspto-grants-1999_10

反应 SMILES

[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:18]3[CH2:17][C:16]4[C:12]([CH:13]=[CH:14][N:15]=4)=[CH:11][C:10]=3[O:9][CH2:8]2)[CH2:4][CH2:3]1.[CH3:19][C:20]1[CH:25]=[C:24]([C:26]2[O:27][C:28]([CH3:31])=[N:29][N:30]=2)[CH:23]=[CH:22][C:21]=1[C:32]1[CH:37]=[CH:36][C:35]([C:38](O)=[O:39])=[CH:34][CH:33]=1.C(N1C2C(=CC(O)=C(Br)C=2)CC1)(=O)C>>[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:18]3[C:10](=[CH:11][C:12]4[CH:13]=[CH:14][N:15]([C:38]([C:35]5[CH:34]=[CH:33][C:32]([C:21]6[CH:22]=[CH:23][C:24]([C:26]7[O:27][C:28]([CH3:31])=[N:29][N:30]=7)=[CH:25][C:20]=6[CH3:19])=[CH:37][CH:36]=5)=[O:39])[C:16]=4[CH:17]=3)[O:9][CH2:8]2)[CH2:4][CH2:3]1