HRID1741104

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10657952

未命名化合物

结构：Cc1nnc(-c2ccc(-c3ccc(C(=O)O)cc3C)cc2C)o1

HCID21833763

未命名化合物

PRODUCTS

生成物

结构：Cc1nnc(-c2ccc(-c3ccc(C(=O)N4CCc5cc6c(cc54)C4(CCN(C)CC4)CO6)cc3C)cc2C)o1

HCID21833715

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 1'-methyl-2,3,6,7-tetrahydrospiro [furo[2,3-f]indole-3,4'-piperidine] (D8) and 2,3'-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxylic acid (D36) using a similar procedure to Example 1 (31%). This was converted to its oxalate salt and crystallised from acetone/methanol as a pale yelloe solid mp. 193-195° C.

WORKUP

后处理

customcrystallised from acetone/methanol as a pale yelloe solid mp. 193-195° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0caeec59b62142ff8db2302da854e7f1
来源数据集: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05972951
来源说明: uspto-grants-1999_10

反应 SMILES

[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:18]3[C:10](=[CH:11][C:12]4[CH2:13][CH2:14][NH:15][C:16]=4[CH:17]=3)[O:9][CH2:8]2)[CH2:4][CH2:3]1.[CH3:19][C:20]1[CH:25]=[C:24]([C:26](O)=[O:27])[CH:23]=[CH:22][C:21]=1[C:29]1[CH:34]=[CH:33][C:32]([C:35]2[O:36][C:37]([CH3:40])=[N:38][N:39]=2)=[C:31]([CH3:41])[CH:30]=1>>[CH3:19][C:20]1[CH:25]=[C:24]([C:26]([N:15]2[C:16]3[CH:17]=[C:18]4[C:5]5([CH2:8][O:9][C:10]4=[CH:11][C:12]=3[CH2:13][CH2:14]2)[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]5)=[O:27])[CH:23]=[CH:22][C:21]=1[C:29]1[CH:34]=[CH:33][C:32]([C:35]2[O:36][C:37]([CH3:40])=[N:38][N:39]=2)=[C:31]([CH3:41])[CH:30]=1