1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → HCID 21833838, compound

HRID 1741105Notes

Reaction equation

HRID 1741105 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[S:9][CH:10]=[C:11]([CH3:13])[N:12]=2)[CH:5]=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=1.[CH3:23][N:24]1[CH2:29][CH2:28][C:27]2([C:40]3[C:32](=[CH:33][C:34]4[CH2:35][CH2:36][NH:37][C:38]=4[CH:39]=3)[O:31][CH2:30]2)[CH2:26][CH2:25]1>>[CH3:23][N:24]1[CH2:25][CH2:26][C:27]2([C:40]3[C:32](=[CH:33][C:34]4[CH2:35][CH2:36][N:37]([C:20]([C:17]5[CH:16]=[CH:15][C:14]([C:3]6[CH:4]=[CH:5][C:6]([C:8]7[S:9][CH:10]=[C:11]([CH3:13])[N:12]=7)=[CH:7][C:2]=6[CH3:1])=[CH:19][CH:18]=5)=[O:21])[C:38]=4[CH:39]=3)[O:31][CH2:30]2)[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 106579521'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine]HCID 21833723HCID 21833723, compound

Product 1

HCID 21833838HCID 21833838, compound

Procedure

The title compound was prepared from 2'-methyl-4'-(4-methylthiazol-2-yl)biphenyl-4-carboxylic acid (D40) and 1'-methyl-2,3,6,7-tetrahydrospiro [furo[2,3-f]indole-3,4'-piperidine] (D8), following the procedure of Example 1. The oxalate salt crystallised from acetone as a buff powder.

Workup

  1. customThe oxalate salt crystallised from acetone as a buff powder

Sources & evidence

ORD record
ord-3d5a93e24181437e9032e1589feffb4a
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

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