1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → HCID 21833821, compound

HRID 1741115Notes

Reaction equation

HRID 1741115 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:18]3[C:10](=[CH:11][C:12]4[CH2:13][CH2:14][NH:15][C:16]=4[CH:17]=3)[O:9][CH2:8]2)[CH2:4][CH2:3]1.[CH3:19][C:20]1[CH:25]=[C:24]([C:26]2[CH:30]=[C:29]([CH3:31])[O:28][N:27]=2)[CH:23]=[CH:22][C:21]=1[C:32]1[CH:37]=[CH:36][C:35]([C:38](O)=[O:39])=[CH:34][CH:33]=1>>[CH3:1][N:2]1[CH2:3][CH2:4][C:5]2([C:18]3[C:10](=[CH:11][C:12]4[CH2:13][CH2:14][N:15]([C:38]([C:35]5[CH:34]=[CH:33][C:32]([C:21]6[CH:22]=[CH:23][C:24]([C:26]7[CH:30]=[C:29]([CH3:31])[O:28][N:27]=7)=[CH:25][C:20]=6[CH3:19])=[CH:37][CH:36]=5)=[O:39])[C:16]=4[CH:17]=3)[O:9][CH2:8]2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 106579521'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine]HCID 21833746HCID 21833746, compound

Product 1

HCID 21833821HCID 21833821, compound

Procedure

The title compound was prepared from 1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine (D8) and 2'-methyl-4'-(5-methylisoxazol-3-yl)biphenyl-4-carboxylic acid (D83) using a procedure similar to that of Example 1 (75%) m.p. 197-9° C.

Sources & evidence

ORD record
ord-db405b069c2f4648b9cdae14eb55790c
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

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