HRID1741117

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCc1nnc(-c2ccc(-c3ccc(C(=O)O)cc3)c(C)c2)o1

HCID21833839

未命名化合物

HCID22115885

未命名化合物

PRODUCTS

生成物

结构：CCc1nnc(-c2ccc(-c3ccc(C(=O)N4CCCc5cc6c(cc54)C4(CCN(C)CC4)CO6)cc3)c(C)c2)o1

HCID21833766

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 4'-(5-ethyl-1,3,4-oxadiazol-2-yl)-2'-methylbiphenyl-4-carboxylic acid (D32) and 2,3,5,6,7,8-hexahydro-1'-methylspiro[furo[2,3-g]quinoline-3,4'-piperidine] (D10) using a procedure similar to that of Example 1 (19%). This was converted to its hydrochloride salt, as a white solid. M.p. 241-3° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-495e6a20db3048e982455e82f0974990
来源数据集: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05972951
来源说明: uspto-grants-1999_10

反应 SMILES

[CH2:1]([C:3]1[O:7][C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=3)=[C:10]([CH3:23])[CH:9]=2)=[N:5][N:4]=1)[CH3:2].[CH3:24][N:25]1[CH2:30][CH2:29][C:28]2([C:42]3[C:33](=[CH:34][C:35]4[CH2:36][CH2:37][CH2:38][NH:39][C:40]=4[CH:41]=3)[O:32][CH2:31]2)[CH2:27][CH2:26]1>>[CH3:24][N:25]1[CH2:30][CH2:29][C:28]2([C:42]3[C:33](=[CH:34][C:35]4[CH2:36][CH2:37][CH2:38][N:39]([C:20]([C:17]5[CH:16]=[CH:15][C:14]([C:11]6[CH:12]=[CH:13][C:8]([C:6]7[O:7][C:3]([CH2:1][CH3:2])=[N:4][N:5]=7)=[CH:9][C:10]=6[CH3:23])=[CH:19][CH:18]=5)=[O:21])[C:40]=4[CH:41]=3)[O:32][CH2:31]2)[CH2:27][CH2:26]1