HRID1741124

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1nnc(-c2ccc(-c3ccc(C(=O)O)cc3)cc2)o1

HCID18797043

未命名化合物

HCID21833744

未命名化合物

PRODUCTS

生成物

结构：CCN1CCC2(CC1)COc1cc3c(cc12)N(C(=O)c1ccc(-c2ccc(-c4nnc(C)o4)cc2)cc1)CC3

HCID21833822

未命名化合物

收率 31%

PROCEDURE

实验过程

The title compound was prepared from 4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxylic acid (D11) and 1'-ethyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (D109) using a similar procedure as that outlined in Example 1, to afford the title compound as a yellow gum (31%). This was converted to its hydrochloride salt to yield an off white solid m.p. 245-249° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1efe16ea59e2420ab79da6e6c297a9d5
来源数据集: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05972951
来源说明: uspto-grants-1999_10

反应 SMILES

[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10]([C:13]3[CH:18]=[CH:17][C:16]([C:19](O)=[O:20])=[CH:15][CH:14]=3)=[CH:9][CH:8]=2)=[N:4][N:3]=1.[CH2:22]([N:24]1[CH2:29][CH2:28][C:27]2([C:40]3[C:32](=[CH:33][C:34]4[CH2:35][CH2:36][NH:37][C:38]=4[CH:39]=3)[O:31][CH2:30]2)[CH2:26][CH2:25]1)[CH3:23]>>[CH2:22]([N:24]1[CH2:29][CH2:28][C:27]2([C:40]3[C:32](=[CH:33][C:34]4[CH2:35][CH2:36][N:37]([C:19]([C:16]5[CH:15]=[CH:14][C:13]([C:10]6[CH:11]=[CH:12][C:7]([C:5]7[O:6][C:2]([CH3:1])=[N:3][N:4]=7)=[CH:8][CH:9]=6)=[CH:18][CH:17]=5)=[O:20])[C:38]=4[CH:39]=3)[O:31][CH2:30]2)[CH2:26][CH2:25]1)[CH3:23]