1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → HCID 18672724, compound

HRID 1741127Notes

Reaction equation

HRID 1741127 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[O:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21](O)=[O:22])=[CH:17][CH:16]=3)=[C:11]([CH3:24])[CH:10]=2)[N:5]=1.[CH3:25][N:26]1[CH2:31][CH2:30][C:29]2([C:42]3[C:34](=[CH:35][C:36]4[CH2:37][CH2:38][NH:39][C:40]=4[CH:41]=3)[O:33][CH2:32]2)[CH2:28][CH2:27]1>>[CH3:1][O:2][CH2:3][C:4]1[O:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([N:39]4[C:40]5[CH:41]=[C:42]6[C:29]7([CH2:32][O:33][C:34]6=[CH:35][C:36]=5[CH2:37][CH2:38]4)[CH2:28][CH2:27][N:26]([CH3:25])[CH2:31][CH2:30]7)=[O:22])=[CH:17][CH:16]=3)=[C:11]([CH3:24])[CH:10]=2)[N:5]=1

Participants

3

Reactant 2

HCID 106579521'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine]HCID 21833807HCID 21833807, compound

Product 1

HCID 18672724HCID 18672724, compoundYield 62%

Procedure

The title compound was prepared from 4'-(5-methoxymethyl-1,2,4-oxadiazol-3-yl)-2'-methylbiphenyl-4-carboxylic acid (D112) and 1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (D8) using a similar procedure as described in Example 1. This afforded the title compound as a pale yellow solid (62%), which was converted to its hydrochloride salt to give an off white solid m.p. 247-251° C.

Sources & evidence

ORD record
ord-f513676a27d1497984f9c35e8c0d2817
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

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