1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → 5-(4'-(5-Methylfuran-2-yl)-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

Participants

Reaction Steps

2'-Methyl-4'-(5-methylfuran-2-yl)biphenyl-4-carboxylic acid (D119) (160 mg, 0.55 mmol) and 1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (D8, 134 mg, 0.55 mmol) were converted to the title compound using the method outlined in Example 29, as an off-white foam (176 mg, 62%).

Provenance & Evidence