HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 17412Generated: October 29, 2026
Triethylamine → 2-(N-tert-Butyl-N-methylamino)-7-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile
https://huagongshe.com/reaction/17412
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (3S)-(-)-3-(Dimethylamino)pyrrolidine | HCID 7019156 | — |
| Reactant | 2-(N-tert-butyl-N-methylamino)-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile | HCID 68583994 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-(N-tert-Butyl-N-methylamino)-7-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile | HCID 68585765 | — |
Reaction Steps
2-(N-tert-butyl-N-methylamino)-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile (I-137) (0.22 g, 0.65 mmol) was suspended in dimethyl sulfoxide (5 ml), then triethylamine (0.19 ml, 1.37 mmol) and (3S)-3-(dimethylamino)pyrrolidine (0.17 ml, 1.34 mmol) were added, followed by stirring in a sealed tube at an external temperature of about 150° C. for 4 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07737166B2 |
|---|
| Source dataset | uspto-grants-2010_06 |
|---|
| ORD ID | ord-87b0b719671b47aba6b796668a5ddd4f |
|---|
| Source note | uspto-grants-2010_06 |
|---|
