HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1741201Generated: October 31, 2026
Toluene → 2-(3-Methoxyphenoxy)-1-(4-methoxyphenyl)ethanone
https://huagongshe.com/reaction/1741201
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Bromomethyl 4-methoxyphenyl ketone | HCID 4965 | — |
| Reactant | 3-Methoxyphenol | HCID 9007 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(3-Methoxyphenoxy)-1-(4-methoxyphenyl)ethanone | HCID 22743054 | — |
Reaction Steps
In a one liter round-bottom flask, fitted with a condenser and nitrogen inlet, were added 3-methoxyphenol (12.4 g, 0.1 mole), 4-methoxyphenacyl bromide (22.9 g, 0.1 mole), potassium carbonate (17.3 g, 0.125 mole) in 100 ml of 2-butanone. This mixture was heated to 80° C. and was maintained at this temperature for about four hours. The progress of the reaction was monitored by thin layer chromatography (silica gel, 9:1 toluene:ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05972888 |
|---|
| Source dataset | uspto-grants-1999_10 |
|---|
| ORD ID | ord-2e2cab4cb73a41388f62ed767c1aec3d |
|---|
| Source note | uspto-grants-1999_10 |
|---|
