5-(4-[2-Aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride → 5-[4-(2-{1-[4-(4-Pyridylsulfonyl)phenyl]ethylideneaminooxy}ethoxy)benzyl]thiazolidine-2,4-dione

Participants

Role	Name	HCID	Charge
Reactant	5-(4-[2-Aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride	HCID 21833965	—
Reactant	1-[4-(Pyridine-4-sulfonyl)phenyl]ethan-1-one	HCID 21833995	—
Product	5-[4-(2-{1-[4-(4-Pyridylsulfonyl)phenyl]ethylideneaminooxy}ethoxy)benzyl]thiazolidine-2,4-dione	HCID 86751823	57.3%

Reaction Steps

Following a procedure similar to that described in Example 40(f), but using 150 mg of 4'-(4-pyridylsulfonyl)acetophenone and 183 mg of 5-[4-(2-aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride [prepared as described in Example 40(e)], 173 mg of the title compound, melting at 213-215° C., were obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05972959
Source dataset	uspto-grants-1999_10
ORD ID	ord-fa15214acfa440e1a5ae8a02b51a5de6
Source note	uspto-grants-1999_10