5-(4-[2-Aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride → 5-(4-{2-[1-(2',4'-Dimethoxybiphenyl-4-yl)ethylideneaminooxy]ethoxy}benzyl)thiazolidine-2,4-dione

Participants

Role	Name	HCID	Charge
Reactant	5-(4-[2-Aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride	HCID 21833965	—
Reactant	1-(2',4'-Dimethoxy-[1,1'-biphenyl]-4-yl)ethanone	HCID 21834044	—
Product	5-(4-{2-[1-(2',4'-Dimethoxybiphenyl-4-yl)ethylideneaminooxy]ethoxy}benzyl)thiazolidine-2,4-dione	HCID 86751825	89.8%

Reaction Steps

Following a procedure similar to that described in Example 40(f), but using 256 mg of 4'-(2,4-dimethoxyphenyl)acetophenone and 382 mg of 5-[4-(2-aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride [prepared as described in Example 40(e)], 467 mg of the title compound, melting at 186-188° C., were obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05972959
Source dataset	uspto-grants-1999_10
ORD ID	ord-e39df9579642476bbf92b640e3ec2522
Source note	uspto-grants-1999_10