反应详情

5 g (21.8 mmol) of N-carboxymethylene-4-chloro-anthranilic acid are introduced into 50 ml of methanol, and 222 mg (2.3 mmol) of sulfuric acid are added. The mixture is heated under reflux for 4 hours and then cooled to room temperature. The product which has precipitated out is filtered off with suction, washed with methanol and dried. 4.0 g (16.4 mmol; 75%) of N-carbomethoxymethylene-4-chloro-anthranilic acid are obtained.

1. additionare added
2. temperatureThe mixture is heated
3. temperatureunder reflux for 4 hours
4. customThe product which has precipitated out
5. filtrationis filtered off with suction
6. washwashed with methanol
7. customdried