Ethanol → HCID 21835787, compound

HRID 1741352Notes

Reaction equation

HRID 1741352 reaction equation
[C:1]([CH:4]=[N:5][C:6]1[C:7](=[C:11]([F:15])[CH:12]=[CH:13][CH:14]=1)[C:8]([OH:10])=[O:9])([OH:3])=[O:2].S(=O)(=O)(O)O.[CH2:21](O)[CH3:22]>>[C:1]([CH:4]=[N:5][C:6]1[C:7](=[C:11]([F:15])[CH:12]=[CH:13][CH:14]=1)[C:8]([OH:10])=[O:9])([O:3][CH2:21][CH3:22])=[O:2]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 21835797HCID 21835797, compound

Product 1

HCID 21835787HCID 21835787, compound

Procedure

10.6 g of N-carboxymethylene-6-fluoro-anthranilic acid having a purity of 73% (corresponding to 39.6 mmol) are suspended in 25 ml of ethanol, 0.98 g (9.6 mmol) of concentrated sulfuric acid are added and the reaction mixture is heated under reflux for 6 hours. It is cooled to room temperature and the product which has precipitated out is filtered off with suction, washed with ethanol and dried.

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureunder reflux for 6 hours
  3. customthe product which has precipitated out
  4. filtrationis filtered off with suction
  5. washwashed with ethanol
  6. customdried

Sources & evidence

ORD record
ord-a06e5a34c598442ca681eb8dcfdad95c
Source dataset
uspto-grants-1999_10
Patent number
US05973189

Reaction notes

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