反应详情

A mixture of (2R)-1-benzyloxycarbonyl-2-(4,5-diphenyloxazol-2-yl)pyrrolidine (4 g) and 10% Pd/C (0.5 g) in ethanol (120 ml) was stirred under H2 for 10 hours. The catalyst was filtered off and filtrate was evaporated in vacuo to give (2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidine. NMR (CDCl3, δ): 1.7-2.3 (4H, m), 2.9-3.2 (2H, m), 3.6-3.8 (1H, m), 4.44 (1H, t, J=6.0 Hz), 7.2-7.7 (10H, m)

1. filtrationThe catalyst was filtered off
2. customfiltrate was evaporated in vacuo